Check out MicrosPy, and open-source microscope from Yuksel Temiz at IBM’s Precision diagnostics group in Zurich.
The project uses a mix of easy-to-source hardware components + Lego bricks and a small handful of custom 3D printed parts. There are several sub-modules that look like they could be useful on their own (e.g., linear actuators that can be built for < $10 using 28BYJ-48 stepper motors).
The total BOM for the system is ~$300 (including a Raspberry pi + HDMI display) and it supports:
- reflected or transmitted light mode
- macro photography
- cross-sectional imaging (e.g., contact angle measurements)
The project also has some of the most stunning documentation I have ever seen in an open-hardware project (and a nice looking video too!). There are definitely lots of options for DIY microscopy these days, but this project looks to fill unique niche and uses an unconventional design that might be useful for other types of projects. The features of this setup seem especially intriguing for anyone in the field of microfluidics, where the combination of macro- and micro-scale imaging could be really useful.